The Role of Androgens in Osteoblast Development and Bone Metabolism

Grant number: 350346

Abstract

Maintenance of the skeleton involves the processes of bone formation by cells known as osteoblasts and bone breakdown by cells known as osteoclasts. When these processes become unbalanced, bone loss results, which is the basis of osteoporosis. The reduced bone mass found in osteoporosis leads to an increased susceptibility to bone fracture. 1 in 2 women and 1 in 3 men over the age of 60 will suffer a fracture due to osteoporosis. The increasing incidence of osteoporotic fractures has lead to renewed efforts to understand the actions of hormones on bone. Androgens, the male sex hormones, have beneficial effects on skeletal growth and bone maintenance in both males and females by stimulating o..

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Related publications (3)

A physiological role for androgen actions in the absence of androgen receptor DNA binding activity

TPS Pang, MV Clarke, A Ghasem-Zadeh, NKL Lee, RA Davey, HE MacLean

2012-01-02

We tested the hypothesis that androgens have physiological actions via non-DNA binding-dependent androgen receptor (AR) signaling ..

DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females

HE MacLean, AJ Moore, SA Sastra, HA Morris, A Ghasem-Zadeh, K Rana, AM Axell, AJ Notini, DJ Handelsman, E Seeman, JD Zajac, RA Davey

2010-07-01

We used our genomic androgen receptor (AR) knockout (ARKO) mouse model, in which the AR is unable to bind DNA to: 1) document gend..

Mineralization and bone resorption are regulated by the androgen receptor in male mice

C Chiang, M Chiu, AJ Moore, PH Anderson, A Ghasem-Zadeh, JF McManus, M Cathy, E Seeman, TL Clemens, HA Morris, JD Zajac, RA Davey

2009-04-01

Androgens play a key role in skeletal growth and bone maintenance; however, their mechanism of action remains unclear. To address ..

University of Melbourne Researchers

Rachel Davey

Jeffrey Zajac